Best Suplements to Reverse Hallmarks of Aging.

What research has to say about the drugs that reduces the hallmarks of aging.

In the early 1900s, life expectancy was around 50 years, but today it’s more than or over 80 years. Possible contributors to this trend include developments in medical treatment and the promotion of cleaner, safer, and healthier living environments.

Numerous chronic illnesses, such as those affecting the brain and blood vessels, include age as a key risk factor. Therefore, aging processes have been proposed as possible targets for developing innovative and generally effective preventatives or treatments for age-related disorders, such as those affecting the brain.

Mankind’s medical progress has come a long way, but there’s still one thing it can’t do: keep us from aging.

Recent research has uncovered mounting evidence for the existence of a “metabolic clock” that regulates the ageing process. Changes to metabolism add up over time, leading to a loss in metabolic balance and overall health and vitality as the clock ticks. To combat ageing and increase longevity, it is essential to treat at its root causes.

Loss of proteostasis, mitochondrial dysfunction, altered nutrient sensing, telomere attrition, genomic instability, cellular senescence, stem cell exhaustion, epigenetic alterations, and altered intercellular communication have all been categorized as “hallmarks of aging” that are thought to contribute to the aging process.

This approach is beneficial since these medications have previously undergone extensive testing for both safety and efficacy in humans and are used daily in clinical settings. Two of them, in particular, such as rapamycin and metformin, have shown a lot of promise in recent research.

But more research is going to focus on reversing the hallmarks of aging. A few of the most studied drugs are,

1. Resveratrol.

Resveratrol is a compound that has recently gained attention as a possible anti-aging treatment by influencing the major hallmarks of aging. According to several animal research, resveratrol influences aging, the onset of age-related illnesses, and longevity.

Human Trials. 

Recent studies lend credence to the idea that resveratrol can extend the lifespan of cells by activating proteins in the cell called sirtuins. Researchers identified natural and synthetic substances, including resveratrol, to stimulate proteins in the past.

Dr. David Sinclair of Harvard Medical School and colleagues found that resveratrol stimulated sirtuins directly; he was on the team that first discovered this effect in 2003. Resveratrol appears to aid in increasing the activity of mitochondria, which provides energy within cells, and may, therefore, reduce the hallmarks of aging.

Different routes of action allow resveratrol to influence a wide range of biological processes, with potential effects on oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, survival, and angiogenesis.


hallmarks of aging and resveratrol

Resveratrol’s effect on hallmarks of aging has been tabulated below, as it has been found to reduce 7 out of 9 hallmarks.

Hallmarks of Aging 
  • Genomic instability. 
  • Telomere shortening. 
  • Epigenetic alternations. 
  • Loss of proteostasis. 
  • Nutrient sensing. 
  • Mitochondrial dysfunction. 
  • Cellular senescence. 
  • Published in Science, explained resveratrol’s chemoprotective function and later demonstrated that it stimulates sirtuin deacetylase and increases longevity.
  • Since resveratrol stimulates sirtuins and blocks mTOR, it is hypothesized to have similar effects on caloric restriction. and nutrient sensing, another hallmark of aging.
  • Resveratrol was also shown to be involved in the preservation of genomic stability, both directly and indirectly, as an anticancer agent.
  • For telomere shortening, it was studied in a review and found that resveratrol’s pro-telomerase effects could protect against the worsening of post-myocadial infarction remodelling.
  • in another study, resveratrol’s antiaging effects can be traced back to its ability to reduce oxidative stress, alleviate inflammation, boost mitochondrial activity, and control apoptosis.

Resveratrol’s safety, effectiveness, and potential therapeutic activities have been the subject of over 244 clinical human investigations and 27 continuing experiments. It has therapeutic promise against a wide range of disorders, including cancer, diabetes, obesity, hypertension, cardiovascular disease, renal disease, inflammation, Alzheimer’s disease, and more. It has been shown to be safe at dosages up to 5g per day.


A naturally occurring polyamine called spermidine has been found to have anti-aging effects. Supplementation with it extends life, boosts stress tolerance, and reduces the onset of age-related disease and movement impairment.

Autophagy, the process of cellular regeneration, is stimulated by spermidine and is responsible for the improvement in the hallmarks of aging. It has the effect of a calorie regulation mimetic (CRM), which means it makes the body react as if it were fasting.  It has also been studied in different research to reduce 6 hallmarks of aging.

Hallmarks of Aging 

  • Telomere shortening. 
  • Epigenetic alternations. 
  • Loss of proteostasis. 
  • Altered cell communication. 
  • Mitochondrial dysfunction. 
  • Stem cell exhaustion. 

This causes autophagy through the TOR kinase pathway, which controls the metabolism of cells and balances the nutrients available when cells are under nutrient tension. During autophagy, cells use their damaged organelles to renew themselves, which is thought to have many anti-aging benefits.

Spermidine protects neurons against inflammation, ischemia, and oxidative stress. Autophagy plays a role in this process by breaking down amyloid-beta proteins. As they accumulate, these plaques in the brain are linked to neurodegenerative disorders like Alzheimer’s. Research suggests that spermidine may be able to delay or even halt the progression of dementia in older adults.


Additionally, spermidine has been linked to enhanced fertility in both sexes.


The ability of NMN to delay and even reverse the effects of aging was one of the most surprising discoveries of the studies on NMN. (1)(2) NMNsupplementation has been demonstrated to prevent or correct a variety of age-related diseases and hallmarks in clinical and animal tests.

30 or more NMN clinical studies involving human participants are listed on

Some research, such as in elderly patients treated with NMN for 12 weeks, showed decreased sleepiness and improved leg function.

In another research, improvements in insulin sensitivity were seen in muscle after 10 weeks of NMN compared to placebo, but not in liver or adipose tissue, in a randomized clinical study including 25 obese postmenopausal women.

Recently, it has been studied that NMN targets 6 out of 9 hallmarks of aging, as in the table below.
Hallmarks of Aging 
  • Genomic instability. 
  • Epigenetic alternations. 
  • Mitochondrial dysfunction. 
  • Stem cell exhaustion. 
  • Altered cellular communication.
  • Cellular senescence. 
  • In mitochondrial dysfunction, it has been shown to improve mitochondrial bioenergetics, reverse the physiological decline that comes with aging, and stop the breakdown of NAD+ and cell death.
  • New research suggests NMN supplementation is associated with anti-atherogenic effects and the enhancement of epigenetic rejuvenation.
  • Another research suggests that NMN can increase the longevity-associated activities activated by AMPK, such as improved mitochondrial health and autophagy (the cellular waste disposal system), via raising NAD+ levels.
  • A study done on bone tissues suggested that nicotinamide mononucleotide (NMN), a key natural NAD+can be utilized in stem cell regeneration.


hallmarks of aging

It has been found that matcha can reduce 4 out of 9 hallmarks of aging as, 

Hallmarks of Aging 
Matcha Tea  

  • Cellular senescence. 
  • Loss of proteostasis.
  • Telomerase shortening.
  • Epigenetic alternations.
  • Recent research demonstrates that matcha tea polyphenols target 200 human genes, including those implicated in inflammation, cancer, diabetes, neurodegenerative, muscular, and cardiovascular illness.
  • Several studies have demonstrated that matcha can prevent liver damage and reduce the chance of developing the liver disease by changing the mechanism of loss of proteins.
  • Another research suggests that matcha tea is beneficial for telomere lengths of DNA, making it a good use for the anti-aging process. In a review of matcha green tea component, curcumin, it was found that it provides many benefits to reduce hallamalrs of aging specially telomerase shortening.
  • Matcha green tea and other high-antioxidant meals have been shown to have anti-aging effects by limiting oxidation, blocking DNA mutation, and repairing damaged DNA.

Modulating gene expression is the underlying biochemical mechanism through which green tea catechins promote the proliferation of new bone-forming cells, reducing the hallmarks of aging.

Improved brain health is also linked to matcha tea drinking, according to a study.

There are antioxidants in matcha tea, but plant compounds also undergo xenohormesis. Molecules like this are produced when plants adapt to harsh environments by producing compounds that alleviate anxiety and delay the effects of aging in humans.

Research is going on in this regard to understand more and more benefits of all of the supplements mentioned above to reverse the hallmarks of aging. There are certainly other drugs/supplements that are specifically helping in reducing the signs and symptoms of aging.

Other Substances.

Senolytics and senomodifiers are another class of medications in development. These try to eliminate senescent cells or alter their behavior. This will prevent the accumulation of these cells and maybe decrease the physical deterioration associated with aging. Dasatinib, navitoclax, quercetin (found in many fruits and vegetables), and fisetin (found in strawberries) are only a few substances identified to be effective in eliminating senescent cells.

Stimulating your longevity genes can also be accomplished by exercising or consuming less food, but resveratrol offers a more consistent solution. In addition to its potential health benefits, resveratrol is frequently used for its effect on the cardiovascular system. We propose taking all the supplements according to your choice if you wish to combat the 9 Hallmarks of Aging at once.

It is never too late to make beneficial changes to your daily routine and use natural supplements to assist your body remain healthy and strong as you age. Amazing as it may be, the human body may be rejuvenated to some extent if given the proper nourishment. The best anti-aging supplement comprises numerous substances that function on various aging pathways.

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Being a Doctor by profession, Aimen is passionate about helping people get better health in their lives. Aimen enjoys her research on Prime With Time subjects and strives to create better awareness of the problems and changes related to women's health.

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